In Vitro Services
Metabolite Profiling and Identification
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IN THIS SECTION
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The identification of metabolic pathways of drug candidates play a key role in drug discovery, pre-clinical, and clinical development.
Metabolite identification studies are critical in supporting the development of your drug candidate. By better understanding the metabolic profile of a drug, insights can be gained relevant to the pharmacokinetics and safety of the compound.
Capabilities:
- Metabolic soft spot determination
- Cross-species metabolite characterization using liver microsomes and hepatocytes with unlabeled and radiolabeled test articles
- Mechanistic studies (reactive metabolites, mechanism of chiral inversion, etc.)
LC/UV Metabolite Profiles of a Test Compound in Hepatocytes
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Discover the following In Vitro services at Frontage
![Metabolite Profiling and Identification](https://www.frontagelab.com/wp-content/uploads/2024/04/Untitled-design-9.png)
Metabolite Profiling and Identification
A key in supporting the development of your drug candidate.
![Kinetics & Metabolic Stability](https://www.frontagelab.com/wp-content/uploads/2024/04/Untitled-design-8.png)
Kinetics & Metabolic Stability
Evaluating pharmacokinetic parameters is essential for determining drug dosing and frequency.
![Drug-Drug Interaction](https://www.frontagelab.com/wp-content/uploads/2024/04/Untitled-design-10.png)
Drug-Drug Interaction
Drug-drug interaction and evaluation is an important undertaking in drug development.
![Permability and Transporters](https://www.frontagelab.com/wp-content/uploads/2024/04/Untitled-design-11.png)
Permability and Transporters
Comprehensive transporter services to support projects from discovery to development.
![Protein Binding and Blood Cell Partitioning](https://www.frontagelab.com/wp-content/uploads/2024/04/Untitled-design-12.png)
Protein Binding and Blood Cell Partitioning
A determinant of both drug elimination and drug pharmacological activity.
Resources To Consider
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![Accurate Mass: The Best Solution For Metabolite Identification In Discovery…](https://www.frontagelab.com/wp-content/uploads/2019/12/shutterstock_128540396-360x180.jpg)
white-paper
Accurate Mass: The Best Solution For Metabolite Identification In…
In this paper, we review appropriate definitions and describe the theoretical basis of why…
![Metabolites in Safety Testing (MIST): Analytical Strategy](https://www.frontagelab.com/wp-content/uploads/2017/04/labs-506712124-360x180.jpg)
webinar
Metabolites in Safety Testing (MIST): Analytical Strategy
In this webinar, Dr. Philip Tiller reviews Metabolites in Safety Testing (MIST) and discus…
![DMPK Services Fact Sheet](https://www.frontagelab.com/wp-content/uploads/2021/07/Resources-335-x-200-3-335x180.png)
fact-sheet
DMPK Services Fact Sheet
At Frontage, we offer extensive drug metabolism and pharmacokinetic capabilities for new c…
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