Radiolabeled Studies

At Frontage we provide a comprehensive suite of radiolabeled studies including in-life administration with radiolabeled compounds, mass balance, pharmacokinetics of total radioactivity and the test compound, and metabolite profiling in plasma, urine, and feces.

• Mass balance and metabolite identification in preclinical species
• Tissue distribution (QWBA) and dosimetry
• Mass balance and metabolite identification in human (hAME)
• Radiolabeled test article synthesis

In vivo metabolism, tissue distribution and mass balance with3H or14C labeled compounds – In life animal dose, sample collection, and sample analysis

• Single or multiple (repeat) doses via various routes
• Intact animals (including JVC/FVC) or BDC rats
• Custom made airtight enclosures for scavenging14C-CO2.
• Sample collection: 2 to 5 days for metabolite profiles/ID and 5 to 7 days for mass balance

Mass Balance and Metabolite Profiling in Bile Duct Cannulated Rats

Discover the following In Vivo services at Frontage

Pharmacokinetics

Pharmacokinetics studies to investigate new chemical entities.

MIST – Metabolites in Safety Testing

A key component of human risk assessment for drug candidates.

Radiolabeled Studies

QWBA Studies

Evaluating the time course of elimination for total radioactivity from tissues in animals.

Human C14 AME (hAME) Study Services

Full-Service Radiolabeled hAME Studies