A GxP-Qualified dPCR-Based RCL Assay to Quantify Replication Competent Lentivirus in Bioanalytical Samples

Lentiviral vectors are widely used in gene and cell therapy for diseases like HIV, cancer, and Parkinson’s. Although they are designed to be replication-incompetent, rare recombination events can allow them to regain replication ability and infect non-target cells. Lentiviral vectors are widely used in gene and cell therapy for diseases like HIV, cancer, and Parkinson’s. Although they are designed to be replication-incompetent, rare recombination events can allow them to regain replication ability and infect non-target cells.

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