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Resource Library / An Unexpected Major Circulating Metabolite M219 Detected in 14C-labeled Human ADME Study of  Brilaroxazine

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An Unexpected Major Circulating Metabolite M219 Detected in 14C-labeled Human ADME Study of  Brilaroxazine

At Frontage Laboratories, a systematic method development approach has been established by continuous monitoring of radioactivity at different study stages, such as in-life mass balance, sample extraction, and column recovery.

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Identification of the Major Circulating Metabolite of Mymd-1 And Elucidation of the Mechanism of Clearance of MYMD-1 in Humans. Role of Aldehyde Oxidase and CYP2A6
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Identification of the Major Circulating Metabolite of Mymd-1 And...
MYMD-1 is an immunomodulator that is currently entering Phase II clinical development for ...
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Metabolites in Safety Testing (MIST): Analytical Strategy
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Metabolites in Safety Testing (MIST): Analytical Strategy
In this webinar, Dr. Philip Tiller reviews Metabolites in Safety Testing (MIST) and discus...
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IN Vitro Assessment of the inhibition of Human Organic Anion Transporting Polypeptide 1B1/1B3 by Highly Bound Plasma Proteins Compounds in the Presence of Physiological Concentration of Human Serum Albumin 
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IN Vitro Assessment of the inhibition of Human Organic Anion...
The present study was aimed to validate this alternate approach to assess inhibition of or...
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Cost Effective and Efficient Progression of Lead Drug Candidates to First in Human Studies
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Cost Effective and Efficient Progression of Lead Drug Candidates to...
Hosted by ISSX, Frontage's own Dr John Kapeghian discusses the "Cost Effective and Efficie...
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Development and validation of an LC-MS/MS method for the quantification of fascin proteins in human serum
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Development and validation of an LC-MS/MS method for the...
Fascin is an actin-bundling protein that has been linked to tumor cell migration, invasion...
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Development and Validation of an LC-MS.MS Method for the Simultaneous Quantitation of Fifteen Bile Acids in Human Serum
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Development and Validation of an LC-MS.MS Method for the Simultaneous...
In this study, we discuss the development and validation of an LC-MS/MS method for the qua...
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Simultaneous Determination of Coproporphyrin-I and Coproporphyrin-III in Human Plasms and Human Urine Using LC-MS/MS
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Simultaneous Determination of Coproporphyrin-I and Coproporphyrin-III...
In this study, we developed and validated an LC-MS/MS method for the simultaneous determin...
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Quantitation of Myostatin/GDF-8 in Human Serum Using ELISA
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Quantitation of Myostatin/GDF-8 in Human Serum Using ELISA
In this study, we validate the ELISA method and deem it to be suitable to quantify GDF8/My...
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Method Validation of Quantitation IL-17A in Human Serum using the Ultrasensitive Quanterix Simoa™ Platform
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Method Validation of Quantitation IL-17A in Human Serum using the...
Interleukin17A (IL-17A) is disulfide-linked homo dimeric cytokine of 155 amino acids and a...
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Determination of Pregabalinin Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry
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Determination of Pregabalinin Human Plasma by Liquid...
Pregabalin, (S)-3-(aminomethyl)-5-methylhexanoic acid, is an analog of the neurotransmitte...
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Development and Validation of an Ultra Sensitive LC-MS/MS Method for Quantitation of Midazolam in Human Plasma
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Development and Validation of an Ultra Sensitive LC-MS/MS Method for...
Midazolam is a widely used central nervous system depressant. It is used for the treatment...
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Comparison of the Quantitative Measurement of Albumin in Human…
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Comparison of the Quantitative Measurement of Albumin in Human…
Human serum albumin (HSA) is the most abundant protein in human blood plasma. This poster ...
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