Quantitative Analysis of Antibody Conjugate Payload by LC MS/MS without Immunocapture

Quantitative analysis of ADC free and conjugated payload and its metabolites is critical to evaluate efficacy, on and off-target toxicity. Liquid chromatography-mass spectrometry (LC-MS) has become a complementary tool to ligand binding assay for ADC analysis owing to its high specificity, sensitivity, and dynamic range. LC-MS based quantitative analysis of conjugated payload is usually coupled with immunocapture of ADC and cleavage of linker.

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