At Frontage, we have extensive knowledge and experience on:

• Route selection, development, and process optimization
• Impurity isolation, identification, synthesis, and control
• Analytical method development and validation
• Non-GMP or GLP drug substances for IND enabling toxicology studies
• Non-GMP key intermediates and GMP starting materials
• GMP drug substances to support clinical trials (from kgs to tons)
• Stability studies, standard preparation
• Tech transfer documentation, CTD, and DMF

Analytical Services Include:

• Chiral analysis  
• Chiral separation 
• Structure characterization (HPLC, LCMS, NMR,…) 
• Purification and purity determination 
• Certificate of Analyses (COA)

Instrumentation and Technology

• NMR
• HPLC, LC-MS and UPLC-MS
• SFC
• GC
• DSC, TGA and ICP
• High-Pressure Reactor
• Microwave Synthesizer
• Photo Reactor and Polarimeter
• Flash Purification Chromatography & prep-HPLC
• Lyophilizer
• High-Throughput Experimentation (HTE) Platform
• Continuous Flow Reactor
• Electronic Lab Notebook (ELN) System