Services & Solutions
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Drug Metabolism & Pharmacokinetics (DMPK)
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In Vitro Services
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Kinetics & Metabolic Stability
Metabolic stability helps evaluate pharmacokinetic parameters, which are essential for determining drug dosing and frequency.
By understanding how a drug is metabolized, it can be optimized with favorable pharmacokinetic properties.
- Metabolic stability in hepatocytes, liver microsomes and other subcellular fractions/tissues of interest
- Intrinsic clearance in recombinant enzymes, liver microsomes and hepatocytes using the parent depletion method
- Vmax and Km determination
Michaels-Menten Kinetics of Metabolite Formation in Human Hepatocytes
| Replicate # | Vmax (pmol/min/million cells) | Km (μM) | CLint (μL/min/million cells) |
|---|---|---|---|
| 1 | 143.2 | 16.19 | 8.845 |
| 2 | 141.8 | 15.37 | 9.226 |
| 3 | 143.8 | 16.53 | 8.699 |
| Mean ± SD | 142.9 ± 1.03 | 16.02 ± 0.60 | 8.923 ± 0.272 |
Discover the following In Vitro services at Frontage
Metabolite Profiling and Identification
A key in supporting the development of your drug candidate.
Kinetics & Metabolic Stability
Evaluating pharmacokinetic parameters is essential for determining drug dosing and frequency.
Drug-Drug Interaction
Drug-drug interaction and evaluation is an important undertaking in drug development.
Permability and Transporters
Comprehensive transporter services to support projects from discovery to development.
Protein Binding and Blood Cell Partitioning
A determinant of both drug elimination and drug pharmacological activity.
Resources To Consider
fact-sheet
DMPK Services Fact Sheet
At Frontage, we offer extensive drug metabolism and pharmacokinetic capabilities for new c…
white-paper
Accurate Mass: The Best Solution For Metabolite Identification In…
In this paper, we review appropriate definitions and describe the theoretical basis of why…
webinar
Metabolites in Safety Testing (MIST): Analytical Strategy
In this webinar, Dr. Philip Tiller reviews Metabolites in Safety Testing (MIST) and discus…
