Services & Solutions
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Drug Metabolism & Pharmacokinetics (DMPK)
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In Vitro Services
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Metabolite Profiling and Identification
The identification of metabolic pathways of drug candidates play a key role in drug discovery, pre-clinical, and clinical development.
Metabolite identification studies are critical in supporting the development of your drug candidate. By better understanding the metabolic profile of a drug, insights can be gained relevant to the pharmacokinetics and safety of the compound.
Capabilities:
- Metabolic soft spot determination
- Cross-species metabolite characterization using liver microsomes and hepatocytes with unlabeled and radiolabeled test articles
- Mechanistic studies (reactive metabolites, mechanism of chiral inversion, etc.)
LC/UV Metabolite Profiles of a Test Compound in Hepatocytes
Discover the following In Vitro services at Frontage
Metabolite Profiling and Identification
A key in supporting the development of your drug candidate.
Kinetics & Metabolic Stability
Evaluating pharmacokinetic parameters is essential for determining drug dosing and frequency.
Drug-Drug Interaction
Drug-drug interaction and evaluation is an important undertaking in drug development.
Permability and Transporters
Comprehensive transporter services to support projects from discovery to development.
Protein Binding and Blood Cell Partitioning
A determinant of both drug elimination and drug pharmacological activity.
Resources To Consider
white-paper
Accurate Mass: The Best Solution For Metabolite Identification In…
In this paper, we review appropriate definitions and describe the theoretical basis of why…
webinar
Metabolites in Safety Testing (MIST): Analytical Strategy
In this webinar, Dr. Philip Tiller reviews Metabolites in Safety Testing (MIST) and discus…
fact-sheet
DMPK Services Fact Sheet
At Frontage, we offer extensive drug metabolism and pharmacokinetic capabilities for new c…
