Comprehensive services in support of advanced development programs.

Gain access to comprehensive biologics services in support of advanced development programs with Frontage’s bioanalytical laboratory.

We have the capabilities to analyze virtually any peptide, protein, oligonucleotide, antibody or antibody-drug conjugates (ADC), and have built a reputation for solving technical challenges related to assay development and validation. 

Frontage’s biologics team have an average of 10 – 15 years in complex drug development and have worked with large molecule applications throughout its evolution in product development. We can handle projects for a range of large molecule development projects including peptides, proteins, monoclonal antibodies, multi-specific antibodies, biosimilars, oligonucleotides, biomarkers, and antibody-drug conjugates. 

• Assay development and validation in complex biological matrix 
• Biological sample analysis (plasma, serum, urine, cerebrospinal fluid, tissue, etc.) 
• Antibody-Drug Conjugates (ADC) 
• Determination of drug/antibody ratio (DAR) and development of DAR insensitive assay for ADC projects 

Capabilities 

• Method development, transfer, and validation 
• PK/TK – Pharmacokinetics assays 
• Macromolecule PK/TK (hybridization and immunoassays) 
• Immunogenicity assays (ADA and NAb) 
• Cell-based assays 
• Functional in vitro assays 
• Toxicity & viability 
• Biomarker services for drug development 

Molecule Types 

• Monoclonal antibodies 
• Antibody conjugates (linker, toxins, MAb, etc)  
• Multi-specific antibodies, antibody fragments  
• Therapeutic proteins  
• Single chain and fusion proteins  
• Peptides  
• Pegylated peptides or proteins 
• Oligonucleotides, Cell & Gene Therapy  

Instrumentation Platforms 

Frontage offers the latest, state-of-the-art instrumentation for large molecule analysis. In addition, we offer Watson LIMS, a validated freezer temperature monitoring system, central security alarm monitoring, and 24-hour card-controlled facility access to ensure the highest levels of data integrity. 

• LC-MS/MS  
• ELISA Assay (Colorimetric, Fluorescence, Chemiluminescence)   
• MSD (Electrochemiluminescence)   
• Quanterix Simoa    
• PCR  
• qPCR  
• ddPCR  
• Gyros  
• Luminex  
• Flow Cytometry  
• ELLA  
• ELISpot 

Small Molecule Bioanalysis • Mass Spectrometry

Reputation for consistent, high-quality project delivery

Large Molecule Bioanalysis • Biologics & Bioassays

Comprehensive services in support of advanced development programs

Cell and Gene Therapy Services

Optimized Methods for Cell and Gene Therapy Products

Antibody Drug Conjugates

Over the past decade, Frontage has provided extensive support for many ADC drugs bioanalysis targeting a variety of antigens