Modalities

Small Molecule Bioanalysis

Services & Solutions / Bioanalytical – Small & Large Molecules / Modalities / Small Molecule Bioanalysis • Mass Spectrometry

Reputation for consistent, high-quality project delivery

Small Molecule Bioanalysis / Mass Spectrometry Based Bioanalysis 

At Frontage, Our laboratories are equipped with state-of-the-art bioanalytical instruments including Sciex 6500+ and 7500 and software programs for the efficient handling of challenging bioanalytical projects. We offer a broad array of mass spectrometry based bioanalysis services. 

Our Small Molecule Bioanalysis Services Include: 

Method development, transfer, partial validation, method qualification and validation, cross validation 
Sample Analysis 
Nonclinical toxicokinetic /pharmacokinetic screening 
Clinical PK/bioavailability studies 
Bioequivalence studies, including highly variable drugs and narrow therapeutical window drugs 
Therapeutic drug monitoring studies 
Drug-drug interaction studies 
Protein binding studies 
Tissue analysis 
Pediatrics bioanalysis involving micro-sampling techniques 
Liposomal drugs 
Inhalant drugs/transdermal patch with ultra-low sensitivity requirement 
Elemental Analysis (Metals) 
Amino acids analysis 
Pegylated drugs 
LNPs 
Chiral compounds requiring chiral separation 
Dose escalation First-In-Human studies  
Global late phase III studies 
Endogenous analytes or biomarker assays 
Multi-domain therapeutical proteins, including mAb, bispecific antibodies, ADCs (antibody-drug conjugates), PDCs (peptide-drug conjugates) 
Oligonucleotides

Our scientific expertise extends to projects that combine small and large-molecule bioanalytical activities such as protein, antibody, antibody-drug conjugates, biomarker analysis , gene and cell therapy drugs as well using mass spectrometry platform. A dedicated biologics LCMS team works together with our sponsors to tackle any bioanalytical challenges beyond the traditional small molecules bioanalysis.  