Address challenging synthetic and medicinal targets.

Our compound screen and lead generation (Hit-to-Lead), lead optimization, process chemistry and manufacturing, and customer synthesis enables speedy advancement of drugs from labs to clinics. Frontage has also partnered with many clients in developing new chemical entities.

Main service areas include:

Custom Synthesis

At Frontage we offer flexibility in support of your custom synthesis project.

Medicinal Chemistry

The right medicinal chemistry approach can be a key differentiator to fast, efficient drug discovery.

Process Chemistry Services & Manufacturing

Our locations in Palo Alto (CA), Exton (PA), Shanghai, Wuhan and Weihai China are developed specifically to cater to these services. See our Worldwide Locations >

Chemistry Services Overview

Custom Synthesis

• Reference compounds
• Building blocks & small libraries
• Intermediates & catalog products
• Impurities, degradants & metabolites
• Chiral synthesis and separation
• Stable isotopes
• Nucleotides, nucleosides and nucleoside triphosphates

Medicinal Chemistry

• Hit confirmation
• Hit-to-lead
• Lead optimization
  • Optimize potency
  • Secure IP
  • Improve ADME properties of lead molecules
  • Pro-drugs

Process Chem R&D and Mfg

• Route selection & process optimization
• Impurity isoloaction, identification, synthesis and control
• Non-GMP drug substances for IND enabling toxicology studies
• Non-GMP key intermediates and GMP starting materials
• Make GMP drug substances to support clinical trial studies
• Tech transfer documentation